Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS
Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...
متن کاملEvaluation of paraoxonase 1 arylesterase activity and lipid peroxide levels in patients with type 1 diabetes.
INTRODUCTION Poor metabolic control of type 1 diabetes is one of the most important factors accelerating the development of late diabetic complications. Several other factors that might contribute to this process are currently being investigated. Low paraoxonase 1 (PON1) activity and high lipid peroxide (LPO) levels contribute to endothelial damage, but it remains unclear whether they are criti...
متن کاملEvaluation of structure of paraoxonase (PON) and its relationship with various diseases
The paraoxonase family in humans includes the PON1, PON2, and PON3 genes. These genes are located on the long arm of chromosome 7 and are structurally similar .Between the nucleotide sequences of these three genes is about 70% and between their amino acid sequences is about 60% compatibility. The three have 9 exons, which in the case of PON1 exists an addition code in position 106 (lysine) i...
متن کاملParaoxonase and arylesterase activity in bladder cancer.
OBJECTIVE Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes. MATERIAL AND METHODS The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enz...
متن کاملParaoxonase-1 and arylesterase activities in patients with colorectal cancer.
BACKGROUND The aim of this study was to evaluate paraoxonase-1 (PON1) and arylesterase (ARE) activities and oxidative stress status in patients with colorectal carcinomas (CRC). MATERIALS AND METHODS Thirty-three patients (20 male, 13 female) with CRC and 30 healthy controls were enrolled in the study. Blood samples were obtained from the CRC patients before adjuvant therapy. Serum samples fr...
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ژورنال
عنوان ژورنال: The International Journal of Biochemistry & Cell Biology
سال: 2016
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2016.06.008